hypoglycemic activity of casearia esculenta roxb. in normal and diabetic albino rats

the hypoglycemic effect of ethanolic extract of casearia esculenta was investigated on alloxan induced diabetic rats. the blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. the ethanolic extract of c. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (p<0.05). it also significantly lowered blood glucose level in alloxan induced diabetic rat from 331.67±4.90 to 130.33±6.53 mg/dl, 3 h after oral administration of the extract (p<0.05). the antihyperglycemic activity of c. esculenta was compared with tolbutamide, an oral hypoglycemic agent.